Arcuate nucleus: difference between revisions
Diff·revision 5 → 6·19:52, 12 Nov 2024
Difference between revision 5 and revision 6 of Arcuate nucleus. 3 lines changed; the page grew by 333 bytes.
| Revision 5 — 20:33, 22 Oct 2024 BetaCellBoyd (talk) expand §Access to circulating signals 2,700 bytes +353 | Revision 6 — 19:52, 12 Nov 2024 GsCouplingGil (talk) add the cleavage site by residue number 3,033 bytes +333 | ||
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| 17 | AgRP/NPY neurons are activated by fasting and by ghrelin, and inhibited by leptin. AgRP is an inverse agonist at melanocortin-4 receptors — it does not merely block α-MSH but reduces constitutive receptor signalling below baseline — and NPY acts at its own receptors to promote feeding. The two populations also inhibit each other directly. | 17 | AgRP/NPY neurons are activated by fasting and by ghrelin, and inhibited by leptin. AgRP is an inverse agonist at melanocortin-4 receptors — it does not merely block α-MSH but reduces constitutive receptor signalling below baseline — and NPY acts at its own receptors to promote feeding. The two populations also inhibit each other directly. |
| 18 | 18 | ||
| + | 19 | The melanocortin-4 receptor is the convergence point, and loss-of-function mutations in it are the commonest known monogenic cause of severe early-onset obesity. Melanocortin agonists developed for other indications act on this same axis; see [[Melanotan II]] and [[Bremelanotide]].{{r|cone2005}} | |
| + | 20 | ||
| 19 | == References == | 21 | == References == |
| 20 | {{reflist}} | 22 | {{reflist}} |
| ⋮ | ⋮ | ||
| 26 | [[Category:Appetite regulation]] | 28 | [[Category:Appetite regulation]] |
| 27 | [[Category:Incretin biology]] | 29 | [[Category:Incretin biology]] |
| + | 30 | [[Category:Receptor pharmacology]] | |
| 28 | 31 |